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Why working at PHO is important to me:

"It is important for me to be part of Public Health Ontario because it’s an organization that offers an environment that is rich in opportunity for collaboration, innovation, and creativity."

Frances Jamieson, Medical microbiologist

Appointments

Academic degrees and accreditations

  • Doctor of medicine, University of Toronto
  • Fellow, The Royal College of Physicians of Canada, Division of Medicine, Medical Microbiology
  • General license, College of Physicians and Surgeons of Ontario
  • Licentiate of the Medical Council of Canada (LMCC), Medical Council of Canada
  • License, National Board of Medical Examiners, United States

Areas of expertise

  • Tuberculosis and mycobacteriology
  • Molecular epidemiology
  • Neisseria meningitidis
  • Haemophilus influenza
  • Bordetella pertussis

PHO research interests

  • Molecular surveillance of new and re-emerging pathogens of public health importance.
  • Mycobacterium tuberculosis: Laboratory diagnosis, molecular epidemiology and whole genome analysis, identification of virulence determinants and molecular basis for drug resistance, and tools for public health.
  • Nontuberculous Mycobacteria (NTM): Laboratory diagnosis, molecular epidemiology, whole genome analysis, identification of virulence determinants and molecular basis for drug resistance, and tools for public health.
  • N. meningitidis: Epidemiology, antibiotic susceptibilities, molecular typing, determination of new methods for serogrouping and phylogeny (whole genome sequencing)
  • Examining the contribution of public health laboratories in the development and implementation of public health policies
  • Advancing the public health laboratories ability to provide diagnostic services and applied research to develop better and more efficient assays, and new techniques that will help in case and outbreak management.
  • Evaluation of new laboratory developed or commercial assays for the direct detection of tuberculosis and drug resistance (in particular, isoniazid and rifampin) from specimens for implementation and improvement of current molecular testing algorithm.

Current PHO research activities

  • Developing and implementing PCR-based genotyping methods for typing of tuberculosis isolates, and the provision of this information in a usable and user-friendly format to public health TB control using a web-based, Geographic Information System (GIS), known as Ontario Universal Typing – Tuberculosis (OUT-TB).
  • Whole genome sequence analysis of M. tuberculosis isolates (Manila lineage) to identify markers for improved genotyping analysis for case and cluster investigations.
  • Application of whole genome sequencing to uncover transmission dynamics and quantify transmission of smear negative TB disease in a high-risk community (Nunavut).
  • Investigating the development and evaluation of improved diagnostic assays for the detection of drug resistance in tuberculosis, and the utilization of whole genome sequencing for the detection of drug resistance.
  • Investigating the epidemiology of non-tuberculosis mycobacteria in Ontario using comparative genomics and other tools, on local clinical and environmental strains, and the geospatial environmental relationship with NTM and drinking water sources and attribution risk.
  • Proteomic, transcriptomic and phenotypic profiling of a M. tuberculosis 15kb natural deletion mutant actively transmitted in the under-housed population in Toronto, Ontario.
  • Investigating the risk of mycobacterial infections associated with inhaled corticosteroids in Ontario.
  • Collaborating on a Canadian Institutes for Health Research grant on the role of Lsr2 in Mycobacterium tuberculosis persistence and drug tolerance.

Other publications

  1. Christianson S, Jamieson FB, Sharma MK, Wolfe J. Appendix D:  Tuberculosis and mycobacteriology laboratory standards: Services and policies. Canadian Tuberculosis Standards, 7th Edition. Edited by Dick Menzies. Canadian Respiratory Journal July/August 2013, Volume 20, Supplement SA. Co-Principal Author.
  2. Pai M, Minion J, Jamieson F, Wolfe J, Behr M. Diagnosis of Active Tuberculosis and Drug Resistance [Chapter]. Canadian Tuberculosis Standards, 7th Edition. Canadian Respiratory Journal July/August 2013, Volume 20, Supplement SA. Coauthor or Collaborator.
  3. Pai M, Kunimoto D, Jamieson F, Menzies D. Diagnosis of Latent Tuberculosis Infection [Chapter]. Canadian Tuberculosis Standards, 7th Edition. Canadian Respiratory Journal July/August 2013, Volume 20, Supplement SA. Coauthor or Collaborator.
  1. Recommendations on Public Health Management of Invasive Group A Streptococcal (iGAS) Disease in Ontario. Ontario Agency for Health Protection and Promotion (Public Health Ontario), Provincial Infectious Diseases Advisory Committee. 2014 Sep 12. Queens Printer for Ontario. Coauthor or Collaborator.
  2. Recommendations from the Clostridium difficile Infection (CDI) Laboratory Best Practices Working Group. 2013 Dec. Ontario Ministry of Health and Long-Term Care. Coauthor or Collaborator.
  3. Public Health Agency of Canada. Guidelines for Tuberculosis Prevention and Control Programs in Canada. December 2012. ISBN: 978-1-100-21896-0. Contributor (Acknowledged).
  4. Kwong JC, Crowcroft NS, Campitelli MA, Ratnasingham S, Daneman N, Deeks SL, Manuel DG, Ontario Burden of Infectious Disease Study Advisory Group. Ontario Burden of Infectious Disease Study (ONBOIDS): An OAHPP/ICES Report. 2010. Coauthor or Collaborator.
  5. Case Definitions for Communicable Diseases Under National Surveillance. CCDR November 2009;35S2 [Supplement] [ISSN 1188-4169]. Contributing Author.
  6. Tuberculosis: Information for Health-Care Providers. 4th Edition, 2009. Ontario Lung Association. Reviewer and Contributor.
  7. A Guide to the Control of Respiratory Infection Outbreaks in Long-Term Care Homes. October 2004. Ontario Ministry of Health and Long-Term Care. Contributing Author.
  8. Guidelines for the Testing and Reporting of Antimicrobial Susceptibilities of Vancomycin Resistant Enterococci. Canadian External Quality Assessment Group for Antimicrobial Resistance, Public Health Agency of Canada, September 1998. [ISBN 0-662-27498-9]. Contributing Author.
  9. Guidelines for the Testing and Reporting of Antimicrobial Susceptibilities of S.pneumoniae. Canadian External Quality Assessment Group for Antimicrobial Resistance, Public Health Agency of Canada, September 1998. [ISBN 0-662-27499-7]. Contributing Author.
  10. Guidelines on susceptibility testing of antibiotic resistant Enterobacteriaceae due to extended spectrum beta-lactamases (ESBLs). Canadian External Quality Assessment Group for Antimicrobial Resistance, Public Health Agency of Canada, September 1998. [ISBN 0-662-02429-X]. Contributing Author.
  11. Guidelines for the testing and reporting of antimicrobial susceptibilities of methicillin resitant Staphylococcus aureus (MRSA) and commentary on methicillin resistant coagulase-negative staphylococci (MR-CNS). Canadian External Quality Assessment Group for Antimicrobial Resistance, Public Health Agency of Canada, September 1998. [ISBN 0-662-27500-4]. Contributing Author.
  12. Institutional viewbook
    1. Data Portal is Key Tool in Infectious Disease Fight. Applied Research 2013 - Centennial College. 2013 Nov. Interviewee.

 

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