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Phagocytosis is a complex and versatile process. It contributes to innate immunity through the ingestion and elimination of pathogens, while also being central to tissue homeostasis and remodeling by clearing effete cells. The ability of phagocytes to perform such diverse functions rests, in large part, on their vast repertoire of receptors. In this seminar, Dr. Grinstein will address the various receptor types, their mobility in the membrane plane and receptor crosstalk. A major part of the talk will be devoted to the actin cytoskeleton, which not only governs receptor mobility and clustering but also is instrumental in particle engulfment. These topics will be viewed in the larger context of the polarization of the phagocytic cells.
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Presenter: Dr. Sergio Grinstein
Dr. Sergio Grinstein completed his Ph.D. in 1976 at the Centro de Investigacion y Estudios Avanzados, in Mexico City. He then spent two years as a post-doctoral fellow at the Hospital For Sick Children in Toronto, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich. He is currently working at the Hospital For Sick Children in Toronto and has been Professor of Biochemistry at the University of Toronto since 1988. Dr. Grinstein is interested in cell physiology and biophysics of innate immunity, particularly phagocytosis and host-pathogen interactions.
PLEASE NOTE: We regret that CME credits cannot be provided for this session.
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