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Clostridium difficile (CD) was considered to be a nuisance until large outbreaks occurred in Montreal, and other North American cities, from 2000 onward.
These outbreaks were associated with an emergence of a novel strain (designated NAP1/027) with increased virulence. Studies of this strain identified a few features not seen in other strains.
Tracing of CD strains using molecular biology methods revealed that one of the features of this strain, an increased transmissibility of spores, might be key to a global spread of this variant. Proper infection control measures minimising this transmission may help to control and prevent outbreaks. In this presentation, Dr. Broukhanski will describe the optimal use of molecular typing methods for CD, and how this can be useful in managing an outbreak.
Presenter: Dr. George Broukhanski
Dr. George Broukhanski is a Molecular Specialist at the Public Health Ontario Laboratories. During his career at this organisation he studied detection and epidemiology of various viral and bacterial infections, such as TB, SARS, Bordetella, norovirus and most recently detection and epidemiology of Clostridium difficile investigating outbreaks in Ontario hospitals and underlying molecular characteristics of this pathogen. He is also an Assistant professor at the department of Laboratory Medicine and Pathobiology, University of Toronto.
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