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PHO Rounds: Microbiology: Imaging phagocytosis: receptors, phosphorylation and the cytoskeleton
Wednesday, April 29, 2015 02:00 pm to 03:00 pm
Venue: 661 University Avenue, 17th floor, Room 17-53, Toronto, Ontario Toronto ON M5G 1H1
Infectious Diseases; Health Promotion; Laboratory Testing and Sciences
City: Toronto
Format: Webinar

​Note: This is an open invitation, and may be forwarded to interested parties.

Phagocytosis is a complex and versatile process. It contributes to innate immunity through the ingestion and elimination of pathogens, while also being central to tissue homeostasis and remodeling by clearing effete cells. The ability of phagocytes to perform such diverse functions rests, in large part, on their vast repertoire of receptors. In this seminar, Dr. Grinstein will address the various receptor types, their mobility in the membrane plane and receptor crosstalk. A major part of the talk will be devoted to the actin cytoskeleton, which not only governs receptor mobility and clustering but also is instrumental in particle engulfment. These topics will be viewed in the larger context of the polarization of the phagocytic cells.

DISCLAIMER: The opinions expressed by speakers and moderators do not necessarily reflect the official policies or views of Public Health Ontario, nor does the mention of trade names, commercial practices, or organizations imply endorsement by Public Health Ontario.

Presenter: Dr. Sergio Grinstein

Dr. Sergio Grinstein completed his Ph.D. in 1976 at the Centro de Investigacion y Estudios Avanzados, in Mexico City.  He then spent two years as a post-doctoral fellow at the Hospital For Sick Children in Toronto, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich.  He is currently working at the Hospital For Sick Children in Toronto and has been Professor of Biochemistry at the University of Toronto since 1988. Dr. Grinstein is interested in cell physiology and biophysics of innate immunity, particularly phagocytosis and host-pathogen interactions.

PLEASE NOTE: We regret that CME credits cannot be provided for this session.


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If you require accommodations to participate in this event, please contact 647-260-7100 or


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